เวชศาสตร์ร่วมสมัย Macro creatine kinase
نویسنده
چکیده
Macro creatine kinase (Macro CK), a macro enzyme, is a major cause of misdiagnosis of myocardial infarction upon determination of total creatine kinase and creatine kinase isoenzyme levels. It presents in elderly female patients with an approximate prevalence of 1 %. Based on composition, there are two major types of macro CK Type 1 macro CK is a complex of Type 1 being an immune complex of creatine kinase with many types of immunoglobulins. Type 1 creatine kinase has been noted for its correlation with autoimmune diseases, especially the myositis group. Type 2 macro CK is a mitochondrion-derived macro CK present in malignancy, especially small cell lung cancer, gastrointestinal cancer and colorectal cancer. The presence of macro CK type 2 is a poor prognostic sign in patients with malignancy.
منابع مشابه
Macro creatine kinase: determination and differentiation of two types by their activation energies.
Determination of the MB isoenzyme of creatine kinase in patients with acute myocardial infarction may be disturbed by the presence of macro creatine kinase. The relative molecular mass of this form of creatine kinase in human serum is at least threefold that of the ordinary enzyme, and it is more thermostable. Here we describe our method for determination of macro creatine kinases and an easy-t...
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Macro creatine kinase (CK, EC 2.7.3.2) and macro lactate dehydrogenase (LD, EC 1.1.1.27) were both present in the serum of a 70-year-old woman with myocardial infarction. This interfered with the interpretation of the CK and LD isoenzyme analyses. Gel filtration and immunoprecipitation showed that the macro CK consisted of IgG and CK and the macro LD of IgG and LD. The IgG in this patient bound...
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Among the conditions in which creatine kinase (CK)-MB activity is elevated in the absence of myocardial injury or infarction, macroenzyme (macro) CK merits special attention from clinicians. We present 2 cases, 1 with macro CK type 1 and the other with macro CK type 2, to stress the common clinical situations and diagnostic dilemma that clinicians encounter when evaluating patients with macro C...
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We examined the case histories of seven pediatric patients (ages four days to 12 years) whose sera showed significant activities of "macro" creatine kinase (CK; EC 2.7.3.2): two cases of macro CK type 1 (CK-BB isoenzyme bound to IgG) and five cases of macro CK type 2 (polymeric complexes of mitochondrial CK). The diagnoses of the two children with macro CK type 1 were similar to those in 55 adu...
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